Ensure that interactive elements are easy to identify
Good design guides the user by communicating purpose and priority. For that reason, every part of the design should be based on an «informed decision» rather than an arbitrary result of personal taste or the current trend.
Provide distinct styles for interactive elements, such as links and buttons, to make them easy to identify. For example, «change the appearance of links» on mouse hover, «keyboard focus», and «touch-screen activation».
Breaking down the barriers
Design is not the end-all solution to all of the worlds problems — but with the right thinking and application, it can definitely be a good beginning to start tackling them.